Drug interactions
Digoxin + Dopamine
Severity: Moderate
Digoxin and Dopamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dopamine enhances myocardial excitability and can precipitate arrhythmias, particularly in patients receiving digoxin. The combined effect may produce serious ventricular ectopy.
What this interaction means in plain words
Digoxin and Dopamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Dopamine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic proarrhythmic effects: catecholamine-driven automaticity combined with digoxin-induced myocardial sensitization.
What to do
Use continuous ECG monitoring during dopamine infusion and use the lowest effective dopamine dose; check potassium and digoxin levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Digoxin and Dopamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Dopamine
- Dihydroergotamine intranasal + Dopamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dopamine + Promethazine Contraindicated
- Dopamine + Selegiline transdermal Contraindicated
- Amitriptyline + Dopamine Major
- Clomipramine + Dopamine Major
Frequently asked questions
Can I take Digoxin with Dopamine?
MediHelp rates the interaction as moderate. Digoxin and Dopamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dopamine enhances myocardial excitability and can precipitate arrhythmias, particularly in patients receiving digoxin. The combined effect may produce serious ventricular ectopy.
How serious is the interaction between Digoxin and Dopamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use continuous ECG monitoring during dopamine infusion and use the lowest effective dopamine dose; check potassium and digoxin levels.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
