Drug interactions
Digoxin + Paromomycin
Severity: Minor
Digoxin and Paromomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral paromomycin, like neomycin, may alter digoxin absorption and gut bacterial metabolism, but data are limited and the effect is poorly characterized.
What this interaction means in plain words
Digoxin and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Paromomycin belongs to Anti Bacterial.
Why it happens
Possible reduced absorption or altered gut flora metabolism of digoxin; not firmly established.
What to do
Monitor digoxin concentrations and clinical response if oral paromomycin is used for a prolonged course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Digoxin with Paromomycin?
MediHelp rates the interaction as minor. Digoxin and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral paromomycin, like neomycin, may alter digoxin absorption and gut bacterial metabolism, but data are limited and the effect is poorly characterized.
How serious is the interaction between Digoxin and Paromomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin concentrations and clinical response if oral paromomycin is used for a prolonged course.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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