Drug interactions
Digoxin + Pretomanid
Severity: Moderate
Digoxin and Pretomanid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid inhibits P-glycoprotein and OATP1B3 in vitro, so it may increase exposure to digoxin. This could raise the risk of digoxin toxicity.
What this interaction means in plain words
Digoxin and Pretomanid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Pretomanid belongs to Anti Bacterial.
Why it happens
Inhibition of P-glycoprotein (and possibly OATP1B3) transport reduces digoxin clearance.
What to do
Monitor digoxin concentrations and for toxicity symptoms during pretomanid therapy, reducing the dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Pretomanid
Frequently asked questions
Can I take Digoxin with Pretomanid?
MediHelp rates the interaction as moderate. Digoxin and Pretomanid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pretomanid inhibits P-glycoprotein and OATP1B3 in vitro, so it may increase exposure to digoxin. This could raise the risk of digoxin toxicity.
How serious is the interaction between Digoxin and Pretomanid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin concentrations and for toxicity symptoms during pretomanid therapy, reducing the dose if needed.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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