Drug interactions
Digoxin + Sotalol
Severity: Moderate
Digoxin and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both slow AV nodal conduction, so together they can cause marked bradycardia and heart block. Bradycardia may also predispose to sotalol-related torsades de pointes.
What this interaction means in plain words
Digoxin and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Sotalol belongs to Cardiovascular.
Why it happens
Additive depression of AV nodal conduction through beta-blockade and vagotonic digoxin effects.
What to do
Monitor heart rate, ECG and digoxin levels and potassium. Reduce doses if symptomatic bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Sotalol?
MediHelp rates the interaction as moderate. Digoxin and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both slow AV nodal conduction, so together they can cause marked bradycardia and heart block. Bradycardia may also predispose to sotalol-related torsades de pointes.
How serious is the interaction between Digoxin and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and digoxin levels and potassium. Reduce doses if symptomatic bradycardia occurs.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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