Drug interactions
Digoxin + Stiripentol
Severity: Moderate
Digoxin and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol may inhibit P-glycoprotein and raise digoxin concentrations. This could lead to digoxin toxicity in patients on stable doses.
What this interaction means in plain words
Digoxin and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Stiripentol belongs to Central Nervous System.
Why it happens
Inhibition of P-glycoprotein efflux reduces digoxin clearance and increases absorption.
What to do
Monitor digoxin levels and toxicity symptoms when starting stiripentol. Lower the digoxin dose if adverse effects or elevated levels occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Digoxin with Stiripentol?
MediHelp rates the interaction as moderate. Digoxin and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol may inhibit P-glycoprotein and raise digoxin concentrations. This could lead to digoxin toxicity in patients on stable doses.
How serious is the interaction between Digoxin and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin levels and toxicity symptoms when starting stiripentol. Lower the digoxin dose if adverse effects or elevated levels occur.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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