Drug interactions
Digoxin + Valbenazine
Severity: Moderate
Digoxin and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valbenazine and its active metabolite can inhibit P-glycoprotein and raise digoxin levels. Digoxin has a narrow therapeutic index, so higher exposure may cause toxicity such as arrhythmias, nausea, and visual disturbance.
What this interaction means in plain words
Digoxin and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Valbenazine belongs to Central Nervous System.
Why it happens
Inhibition of intestinal and renal P-glycoprotein reduces digoxin efflux and clearance.
What to do
Monitor serum digoxin concentrations when starting or stopping valbenazine, and adjust the digoxin dose based on levels and clinical signs of toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Valbenazine?
MediHelp rates the interaction as moderate. Digoxin and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valbenazine and its active metabolite can inhibit P-glycoprotein and raise digoxin levels. Digoxin has a narrow therapeutic index, so higher exposure may cause toxicity such as arrhythmias, nausea, and visual disturbance.
How serious is the interaction between Digoxin and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin concentrations when starting or stopping valbenazine, and adjust the digoxin dose based on levels and clinical signs of toxicity.
What other medicines interact with Valbenazine?
MediHelp also lists interactions of Valbenazine with, for example, Deutetrabenazine, Tranylcypromine, Amiodarone. The full list is on the Valbenazine page.
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