Drug interactions
Digoxin + Vitamin d
Severity: Moderate
Digoxin and Vitamin d: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High-dose vitamin D can cause hypercalcemia, which increases the sensitivity of the heart to digoxin. This raises the risk of serious arrhythmias.
What this interaction means in plain words
Digoxin and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Vitamin d belongs to Gastrointestinal Tract.
Why it happens
Hypercalcemia has additive effects with digoxin on myocardial excitability and automaticity.
What to do
Monitor serum calcium in patients on digoxin who take vitamin D at high doses. Reduce the vitamin D dose if hypercalcemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Vitamin d
Frequently asked questions
Can I take Digoxin with Vitamin d?
MediHelp rates the interaction as moderate. Digoxin and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. High-dose vitamin D can cause hypercalcemia, which increases the sensitivity of the heart to digoxin. This raises the risk of serious arrhythmias.
How serious is the interaction between Digoxin and Vitamin d?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium in patients on digoxin who take vitamin D at high doses. Reduce the vitamin D dose if hypercalcemia occurs.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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