Drug interactions
Dihydroergotamine + Risperidone
Severity: Moderate
Dihydroergotamine and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs may influence serotonergic and dopaminergic signalling, and antipsychotics combined with serotonergic agents have been linked to serotonin syndrome or neuroleptic malignant syndrome in rare reports. The evidence for dihydroergotamine specifically is limited. Risperidone's alpha-blockade could also theoretically add to vascular effects.
What this interaction means in plain words
Dihydroergotamine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dihydroergotamine belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Possible additive serotonergic and dopaminergic modulation; mechanism not firmly established.
What to do
Monitor for mental status change, hyperthermia, rigidity and autonomic instability after starting. Stop dihydroergotamine if toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dihydroergotamine and Risperidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Risperidone?
MediHelp rates the interaction as moderate. Dihydroergotamine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs may influence serotonergic and dopaminergic signalling, and antipsychotics combined with serotonergic agents have been linked to serotonin syndrome or neuroleptic malignant syndrome in rare reports. The evidence for dihydroergotamine specifically is limited. Risperidone's alpha-blockade could also theoretically add to vascular effects.
How serious is the interaction between Dihydroergotamine and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status change, hyperthermia, rigidity and autonomic instability after starting. Stop dihydroergotamine if toxicity is suspected.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
