Drug interactions
Dihydroergotamine + Sotalol
Severity: Moderate
Dihydroergotamine and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dihydroergotamine causes vasoconstriction, and beta-blockers may blunt beta-2-mediated vasodilation, so peripheral ischemia or vasospasm could be potentiated. The effect is reported mainly with ergot alkaloids and non-selective beta-blockers.
What this interaction means in plain words
Dihydroergotamine and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dihydroergotamine belongs to Central Nervous System; Sotalol belongs to Cardiovascular.
Why it happens
Ergot alpha-adrenergic vasoconstriction is unopposed when beta-2 vasodilation is blocked.
What to do
Monitor for cold extremities, paresthesias, or chest pain. Stop the ergot and seek review if ischemic symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Sotalol?
MediHelp rates the interaction as moderate. Dihydroergotamine and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dihydroergotamine causes vasoconstriction, and beta-blockers may blunt beta-2-mediated vasodilation, so peripheral ischemia or vasospasm could be potentiated. The effect is reported mainly with ergot alkaloids and non-selective beta-blockers.
How serious is the interaction between Dihydroergotamine and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cold extremities, paresthesias, or chest pain. Stop the ergot and seek review if ischemic symptoms develop.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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