Drug interactions
Dihydroergotamine + Trazodone
Severity: Moderate
Dihydroergotamine and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both have serotonergic activity, so combined use may raise the risk of serotonin syndrome. Trazodone is also a CYP3A4 substrate with weak inhibitory effects, and dihydroergotamine toxicity (ergotism, vasospasm) is a concern with CYP3A4 inhibition.
What this interaction means in plain words
Dihydroergotamine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dihydroergotamine belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive serotonergic effects, with a possible minor pharmacokinetic contribution via CYP3A4.
What to do
Monitor for serotonin syndrome and for signs of peripheral ischemia such as cold or numb extremities. Stop the combination if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Trazodone?
MediHelp rates the interaction as moderate. Dihydroergotamine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both have serotonergic activity, so combined use may raise the risk of serotonin syndrome. Trazodone is also a CYP3A4 substrate with weak inhibitory effects, and dihydroergotamine toxicity (ergotism, vasospasm) is a concern with CYP3A4 inhibition.
How serious is the interaction between Dihydroergotamine and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome and for signs of peripheral ischemia such as cold or numb extremities. Stop the combination if symptoms appear.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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