Drug interactions
Dihydroergotamine + Trimipramine
Severity: Moderate
Dihydroergotamine and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination may add to serotonergic activity and peripheral vasoconstriction. Serotonin syndrome is a theoretical risk, and ergot toxicity is more likely if dihydroergotamine exposure rises.
What this interaction means in plain words
Dihydroergotamine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dihydroergotamine belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Additive serotonergic and vasoconstrictive effects.
What to do
Monitor for serotonin toxicity and for signs of ischemia such as cold extremities or chest pain. Stop dihydroergotamine if such symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Trimipramine?
MediHelp rates the interaction as moderate. Dihydroergotamine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination may add to serotonergic activity and peripheral vasoconstriction. Serotonin syndrome is a theoretical risk, and ergot toxicity is more likely if dihydroergotamine exposure rises.
How serious is the interaction between Dihydroergotamine and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin toxicity and for signs of ischemia such as cold extremities or chest pain. Stop dihydroergotamine if such symptoms occur.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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