Drug interactions
Disopyramide + Eslicarbazepine
Severity: Moderate
Disopyramide and Eslicarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine may reduce disopyramide levels and lead to loss of antiarrhythmic control. Altered levels of its active metabolite may also change anticholinergic effects.
What this interaction means in plain words
Disopyramide and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Disopyramide belongs to Cardiovascular; Eslicarbazepine belongs to Central Nervous System.
Why it happens
CYP3A4 induction increases disopyramide metabolism.
What to do
Monitor ECG and arrhythmia control, and consider disopyramide serum levels. Adjust the dose when eslicarbazepine is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Eslicarbazepine?
MediHelp rates the interaction as moderate. Disopyramide and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine may reduce disopyramide levels and lead to loss of antiarrhythmic control. Altered levels of its active metabolite may also change anticholinergic effects.
How serious is the interaction between Disopyramide and Eslicarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and arrhythmia control, and consider disopyramide serum levels. Adjust the dose when eslicarbazepine is started or stopped.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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