Drug interactions
Disopyramide + Insulin glargine
Severity: Moderate
Disopyramide and Insulin glargine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide can cause hypoglycemia, sometimes severe, and this may add to the effect of insulin. Patients with diabetes, renal impairment or poor nutrition may be at higher risk.
What this interaction means in plain words
Disopyramide and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Disopyramide belongs to Cardiovascular; Insulin glargine belongs to Endocrine.
Why it happens
Disopyramide may increase insulin secretion and impair glucose counterregulation; the effect adds to exogenous insulin.
What to do
Increase blood glucose monitoring when disopyramide is started or stopped and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Insulin glargine?
MediHelp rates the interaction as moderate. Disopyramide and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Disopyramide can cause hypoglycemia, sometimes severe, and this may add to the effect of insulin. Patients with diabetes, renal impairment or poor nutrition may be at higher risk.
How serious is the interaction between Disopyramide and Insulin glargine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase blood glucose monitoring when disopyramide is started or stopped and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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