Drug interactions
Disopyramide + Mefloquine
Severity: Major
Disopyramide and Mefloquine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and together they may add to the risk of torsades de pointes and other ventricular arrhythmias. Disopyramide is a class Ia antiarrhythmic with notable proarrhythmic potential, which makes the combination particularly risky.
What this interaction means in plain words
Disopyramide and Mefloquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Disopyramide belongs to Cardiovascular; Mefloquine belongs to Anti Parasitic.
Why it happens
Additive prolongation of cardiac repolarization (QT interval) through pharmacodynamic effects of both drugs.
What to do
Avoid concurrent use and select a non-QT-prolonging antimalarial. If unavoidable, obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Mefloquine?
MediHelp rates the interaction as major. Disopyramide and Mefloquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and together they may add to the risk of torsades de pointes and other ventricular arrhythmias. Disopyramide is a class Ia antiarrhythmic with notable proarrhythmic potential, which makes the combination particularly risky.
How serious is the interaction between Disopyramide and Mefloquine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and select a non-QT-prolonging antimalarial. If unavoidable, obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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