Drug interactions
Disopyramide + Sarilumab
Severity: Moderate
Disopyramide and Sarilumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
IL-6 blockade can restore CYP enzyme activity that inflammation had suppressed, potentially lowering levels of CYP substrates. Disopyramide, which has a narrow therapeutic range and is metabolized by CYP3A4, may become less effective.
What this interaction means in plain words
Disopyramide and Sarilumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Disopyramide belongs to Cardiovascular; Sarilumab belongs to Musculoskeletal.
Why it happens
Sarilumab reverses IL-6-mediated downregulation of CYP3A4, increasing disopyramide metabolism.
What to do
Monitor arrhythmia control and disopyramide concentrations or ECG when starting or stopping sarilumab, and adjust the dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Disopyramide and Sarilumab, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sarilumab
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Sarilumab?
MediHelp rates the interaction as moderate. Disopyramide and Sarilumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. IL-6 blockade can restore CYP enzyme activity that inflammation had suppressed, potentially lowering levels of CYP substrates. Disopyramide, which has a narrow therapeutic range and is metabolized by CYP3A4, may become less effective.
How serious is the interaction between Disopyramide and Sarilumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor arrhythmia control and disopyramide concentrations or ECG when starting or stopping sarilumab, and adjust the dose as needed.
What other medicines interact with Sarilumab?
MediHelp also lists interactions of Sarilumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Dengue vaccine. The full list is on the Sarilumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
