Drug interactions
Disopyramide + Solifenacin
Severity: Major
Disopyramide and Solifenacin: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have anticholinergic activity, and disopyramide is a recognized QT-prolonging antiarrhythmic. Together they can increase the risk of QT prolongation and torsades de pointes, as well as dry mouth, urinary retention and constipation.
What this interaction means in plain words
Disopyramide and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Disopyramide belongs to Cardiovascular; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT prolongation and additive antimuscarinic effects.
What to do
Avoid the combination where possible, or obtain an ECG and monitor electrolytes and anticholinergic effects; consider an alternative bladder agent with less QT risk.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Solifenacin 10 mg film-coated tablets - SmPC sections 4.3/4.5 (class statement: anticholinergic properties; "Concomitant medication with other medicinal products with anticholinergic properties may result in more pronounced therapeutic effects and undesirable effects.") — electronic medicines compendium (UK SmPC)
Other interactions of Solifenacin
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Solifenacin?
MediHelp rates the interaction as major. Disopyramide and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs have anticholinergic activity, and disopyramide is a recognized QT-prolonging antiarrhythmic. Together they can increase the risk of QT prolongation and torsades de pointes, as well as dry mouth, urinary retention and constipation.
How serious is the interaction between Disopyramide and Solifenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or obtain an ECG and monitor electrolytes and anticholinergic effects; consider an alternative bladder agent with less QT risk.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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