Drug interactions
Dofetilide + Fluticasone-vilanterol
Severity: Major
Dofetilide and Fluticasone-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dofetilide has a dose-dependent risk of torsade de pointes, and beta2-agonists may add to this via hypokalemia and increased heart rate. The combination can increase the risk of life-threatening arrhythmia.
What this interaction means in plain words
Dofetilide and Fluticasone-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dofetilide belongs to Cardiovascular; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
Additive QT prolongation with beta2-agonist-related hypokalemia and tachycardia.
What to do
Keep potassium and magnesium normal and monitor ECG and QTc, particularly after dofetilide initiation. Use an alternative to the LABA if clinically possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-vilanterol
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Fluticasone-vilanterol?
MediHelp rates the interaction as major. Dofetilide and Fluticasone-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dofetilide has a dose-dependent risk of torsade de pointes, and beta2-agonists may add to this via hypokalemia and increased heart rate. The combination can increase the risk of life-threatening arrhythmia.
How serious is the interaction between Dofetilide and Fluticasone-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep potassium and magnesium normal and monitor ECG and QTc, particularly after dofetilide initiation. Use an alternative to the LABA if clinically possible.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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