Drug interactions
Dofetilide + Linagliptin-metformin
Severity: Moderate
Dofetilide and Linagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are cationic and handled by renal tubular secretion via OCT2 and MATE transporters, so competition could increase metformin or dofetilide levels. Raised dofetilide concentrations carry a risk of QT prolongation and torsades de pointes, which makes this more important than the metformin effect.
What this interaction means in plain words
Dofetilide and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dofetilide belongs to Cardiovascular; Linagliptin-metformin belongs to Endocrine.
Why it happens
Competition for renal tubular cationic secretion (OCT2/MATE) may reduce clearance of metformin and dofetilide.
What to do
Monitor ECG and QTc, particularly when starting the combination, and watch renal function and signs of metformin accumulation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Linagliptin-metformin?
MediHelp rates the interaction as moderate. Dofetilide and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are cationic and handled by renal tubular secretion via OCT2 and MATE transporters, so competition could increase metformin or dofetilide levels. Raised dofetilide concentrations carry a risk of QT prolongation and torsades de pointes, which makes this more important than the metformin effect.
How serious is the interaction between Dofetilide and Linagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and QTc, particularly when starting the combination, and watch renal function and signs of metformin accumulation.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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