Drug interactions
Dofetilide + Quetiapine
Severity: Major
Dofetilide and Quetiapine: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dofetilide markedly prolongs the QT interval and quetiapine adds further prolongation, which raises the risk of torsades de pointes. Risk increases with renal impairment, hypokalemia, hypomagnesemia and bradycardia.
What this interaction means in plain words
Dofetilide and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dofetilide belongs to Cardiovascular; Quetiapine belongs to Central Nervous System.
Why it happens
Additive QT prolongation from potassium channel (hERG) blockade.
What to do
Avoid the combination where possible and choose an antipsychotic with minimal QT effect. If used, monitor ECG and QTc closely and keep electrolytes normal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Biquelle XL 150mg prolonged-release tablets - SmPC sections 4.3/4.5 (class statement: medicinal products known to cause electrolyte imbalance or to increase QT interval; "Caution should be exercised when quetiapine is used concomitantly with medicinal products known to cause electrolyte imbalance o… — electronic medicines compendium (UK SmPC)
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Quetiapine?
MediHelp rates the interaction as major. Dofetilide and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dofetilide markedly prolongs the QT interval and quetiapine adds further prolongation, which raises the risk of torsades de pointes. Risk increases with renal impairment, hypokalemia, hypomagnesemia and bradycardia.
How serious is the interaction between Dofetilide and Quetiapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose an antipsychotic with minimal QT effect. If used, monitor ECG and QTc closely and keep electrolytes normal.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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