Drug interactions
Dofetilide + Saxagliptin-metformin
Severity: Moderate
Dofetilide and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dofetilide and metformin are both cationic drugs secreted by renal tubular transporters, and competition may raise metformin levels. The clinical effect is generally small, though lactic acidosis is a concern in patients with renal impairment.
What this interaction means in plain words
Dofetilide and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dofetilide belongs to Cardiovascular; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Competition for renal tubular cationic secretion (OCT2/MATE) may reduce metformin clearance.
What to do
Monitor renal function and watch for signs of metformin excess such as lactic acidosis. Reduce the metformin dose if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Dofetilide and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dofetilide and metformin are both cationic drugs secreted by renal tubular transporters, and competition may raise metformin levels. The clinical effect is generally small, though lactic acidosis is a concern in patients with renal impairment.
How serious is the interaction between Dofetilide and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and watch for signs of metformin excess such as lactic acidosis. Reduce the metformin dose if renal function declines.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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