Drug interactions
Dofetilide + Ziprasidone
Severity: Contraindicated
Dofetilide and Ziprasidone: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong ventricular repolarization, and giving them together adds to the risk of marked QTc prolongation and torsades de pointes. Dofetilide already carries a substantial proarrhythmic risk, and ziprasidone is labeled against use with other QT-prolonging agents.
What this interaction means in plain words
Dofetilide and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dofetilide belongs to Cardiovascular; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive blockade of the hERG potassium current (IKr), causing additive QT prolongation.
What to do
Do not combine; choose an antipsychotic with less QT effect if dofetilide is required. If the patient is already on dofetilide, review the need for any QT-prolonging psychotropic.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Ziprasidone?
MediHelp rates the interaction as contraindicated. Dofetilide and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong ventricular repolarization, and giving them together adds to the risk of marked QTc prolongation and torsades de pointes. Dofetilide already carries a substantial proarrhythmic risk, and ziprasidone is labeled against use with other QT-prolonging agents.
How serious is the interaction between Dofetilide and Ziprasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose an antipsychotic with less QT effect if dofetilide is required. If the patient is already on dofetilide, review the need for any QT-prolonging psychotropic.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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