Drug interactions
Dolasetron + Eletriptan
Severity: Moderate
Dolasetron and Eletriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have serotonergic activity, and serotonin syndrome has been reported with 5-HT3 antagonists combined with triptans. The risk is thought to be low but clinically important if it occurs.
What this interaction means in plain words
Dolasetron and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Eletriptan belongs to Central Nervous System.
Why it happens
Theoretical additive serotonergic effects; the mechanism is not firmly established.
What to do
Monitor for features of serotonin toxicity when used together, particularly after dose changes. Stop both and treat supportively if it develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Dolasetron with Eletriptan?
MediHelp rates the interaction as moderate. Dolasetron and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have serotonergic activity, and serotonin syndrome has been reported with 5-HT3 antagonists combined with triptans. The risk is thought to be low but clinically important if it occurs.
How serious is the interaction between Dolasetron and Eletriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for features of serotonin toxicity when used together, particularly after dose changes. Stop both and treat supportively if it develops.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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