Drug interactions
Dolasetron + Gepirone
Severity: Major
Dolasetron and Gepirone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gepirone carries a QT-prolongation warning and is contraindicated with other QT-prolonging drugs per its labeling. Adding dolasetron increases the risk of serious ventricular arrhythmias including torsades de pointes.
What this interaction means in plain words
Dolasetron and Gepirone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dolasetron belongs to Gastrointestinal Tract; Gepirone belongs to Central Nervous System.
Why it happens
Additive prolongation of the QT interval.
What to do
Avoid the combination and use an antiemetic with minimal QT effect. If it cannot be avoided, correct electrolytes and monitor ECG closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Dolasetron with Gepirone?
MediHelp rates the interaction as major. Dolasetron and Gepirone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gepirone carries a QT-prolongation warning and is contraindicated with other QT-prolonging drugs per its labeling. Adding dolasetron increases the risk of serious ventricular arrhythmias including torsades de pointes.
How serious is the interaction between Dolasetron and Gepirone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an antiemetic with minimal QT effect. If it cannot be avoided, correct electrolytes and monitor ECG closely.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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