Drug interactions
Dolasetron + Goserelin
Severity: Moderate
Dolasetron and Goserelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with goserelin may prolong the QT interval, and dolasetron adds to this. The combination can increase risk of torsades de pointes in patients with other risk factors.
What this interaction means in plain words
Dolasetron and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Goserelin belongs to Endocrine.
Why it happens
Additive QT prolongation.
What to do
Check baseline ECG and electrolytes and monitor in patients with cardiac disease. Consider an antiemetic with less QT effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Goserelin
Frequently asked questions
Can I take Dolasetron with Goserelin?
MediHelp rates the interaction as moderate. Dolasetron and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with goserelin may prolong the QT interval, and dolasetron adds to this. The combination can increase risk of torsades de pointes in patients with other risk factors.
How serious is the interaction between Dolasetron and Goserelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes and monitor in patients with cardiac disease. Consider an antiemetic with less QT effect.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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