Drug interactions
Dolasetron + Indacaterol
Severity: Moderate
Dolasetron and Indacaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dolasetron's active metabolite prolongs PR, QRS and QT intervals, and indacaterol may add cardiac stimulation and hypokalemia. Concurrent use may raise the risk of ventricular arrhythmias.
What this interaction means in plain words
Dolasetron and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Indacaterol belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta-2 agonist related hypokalemia as a possible contributor.
What to do
Consider an alternative antiemetic such as one with less QT effect in patients at risk. Correct potassium and magnesium and monitor the ECG if used together.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Frequently asked questions
Can I take Dolasetron with Indacaterol?
MediHelp rates the interaction as moderate. Dolasetron and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dolasetron's active metabolite prolongs PR, QRS and QT intervals, and indacaterol may add cardiac stimulation and hypokalemia. Concurrent use may raise the risk of ventricular arrhythmias.
How serious is the interaction between Dolasetron and Indacaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antiemetic such as one with less QT effect in patients at risk. Correct potassium and magnesium and monitor the ECG if used together.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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