Drug interactions
Dolasetron + Levoketoconazole
Severity: Major
Dolasetron and Levoketoconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole causes dose-related QT prolongation and its labeling contraindicates use with other QT-prolonging drugs that are CYP3A4 substrates or otherwise raise torsades risk. Dolasetron adds to this risk of serious ventricular arrhythmia.
What this interaction means in plain words
Dolasetron and Levoketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dolasetron belongs to Gastrointestinal Tract; Levoketoconazole belongs to Endocrine.
Why it happens
Additive QT prolongation; levoketoconazole may also inhibit CYP3A4-mediated clearance of dolasetron metabolites.
What to do
Avoid coadministration and use a non-QT-prolonging antiemetic such as one from another class. If unavoidable, correct electrolytes and monitor ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Dolasetron with Levoketoconazole?
MediHelp rates the interaction as major. Dolasetron and Levoketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Levoketoconazole causes dose-related QT prolongation and its labeling contraindicates use with other QT-prolonging drugs that are CYP3A4 substrates or otherwise raise torsades risk. Dolasetron adds to this risk of serious ventricular arrhythmia.
How serious is the interaction between Dolasetron and Levoketoconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration and use a non-QT-prolonging antiemetic such as one from another class. If unavoidable, correct electrolytes and monitor ECG.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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