Drug interactions
Dolasetron + Midostaurin
Severity: Major
Dolasetron and Midostaurin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midostaurin has been associated with QT prolongation, and dolasetron adds to this effect. The combination raises the risk of ventricular arrhythmia.
What this interaction means in plain words
Dolasetron and Midostaurin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dolasetron belongs to Gastrointestinal Tract; Midostaurin belongs to Oncology.
Why it happens
Additive QT interval prolongation.
What to do
Prefer an antiemetic with less QT effect. If co-use is needed, monitor ECG and electrolytes and correct abnormalities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Midostaurin
Frequently asked questions
Can I take Dolasetron with Midostaurin?
MediHelp rates the interaction as major. Dolasetron and Midostaurin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Midostaurin has been associated with QT prolongation, and dolasetron adds to this effect. The combination raises the risk of ventricular arrhythmia.
How serious is the interaction between Dolasetron and Midostaurin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antiemetic with less QT effect. If co-use is needed, monitor ECG and electrolytes and correct abnormalities.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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