Drug interactions
Dolasetron + Rizatriptan
Severity: Moderate
Dolasetron and Rizatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs act on the serotonin system, and 5-HT3 antagonists combined with triptans have been linked to rare serotonin syndrome. Most patients tolerate the combination, but the reaction can be serious.
What this interaction means in plain words
Dolasetron and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Rizatriptan belongs to Central Nervous System.
Why it happens
Possible additive serotonergic activity; the mechanism is largely theoretical.
What to do
Counsel the patient on symptoms of serotonin toxicity and monitor after starting or increasing doses. Stop treatment if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Frequently asked questions
Can I take Dolasetron with Rizatriptan?
MediHelp rates the interaction as moderate. Dolasetron and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs act on the serotonin system, and 5-HT3 antagonists combined with triptans have been linked to rare serotonin syndrome. Most patients tolerate the combination, but the reaction can be serious.
How serious is the interaction between Dolasetron and Rizatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient on symptoms of serotonin toxicity and monitor after starting or increasing doses. Stop treatment if symptoms develop.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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