Drug interactions
Dolasetron + Tedizolid
Severity: Moderate
Dolasetron and Tedizolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tedizolid is a weak reversible MAO inhibitor, so it may add to serotonergic effects of other drugs. Serotonin syndrome with a 5-HT3 antagonist is possible, though clinical data for tedizolid are limited.
What this interaction means in plain words
Dolasetron and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Tedizolid belongs to Anti Bacterial.
Why it happens
Possible additive serotonergic effect from weak MAO inhibition with 5-HT3 antagonism.
What to do
Monitor for signs of serotonin syndrome during co-administration. Use another antiemetic if the patient has other serotonergic exposures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Frequently asked questions
Can I take Dolasetron with Tedizolid?
MediHelp rates the interaction as moderate. Dolasetron and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tedizolid is a weak reversible MAO inhibitor, so it may add to serotonergic effects of other drugs. Serotonin syndrome with a 5-HT3 antagonist is possible, though clinical data for tedizolid are limited.
How serious is the interaction between Dolasetron and Tedizolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin syndrome during co-administration. Use another antiemetic if the patient has other serotonergic exposures.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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