Drug interactions
Dolasetron + Tiotropium-olodaterol
Severity: Moderate
Dolasetron and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dolasetron's active metabolite prolongs the PR, QRS and QT intervals, and olodaterol may add to arrhythmia risk through sympathetic stimulation and lower potassium. The concern is greatest in patients with cardiac disease or electrolyte abnormalities.
What this interaction means in plain words
Dolasetron and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive effects on cardiac conduction and repolarization with beta2-mediated sympathetic stimulation.
What to do
Correct potassium and magnesium before use and obtain an ECG in at-risk patients. Consider an antiemetic with less QT effect if risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Frequently asked questions
Can I take Dolasetron with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Dolasetron and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dolasetron's active metabolite prolongs the PR, QRS and QT intervals, and olodaterol may add to arrhythmia risk through sympathetic stimulation and lower potassium. The concern is greatest in patients with cardiac disease or electrolyte abnormalities.
How serious is the interaction between Dolasetron and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before use and obtain an ECG in at-risk patients. Consider an antiemetic with less QT effect if risk is high.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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