Drug interactions
Dolasetron + Trimipramine
Severity: Moderate
Dolasetron and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can prolong the QT interval and have serotonergic activity. With dolasetron this raises the potential for arrhythmia and, rarely, serotonin syndrome.
What this interaction means in plain words
Dolasetron and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Trimipramine belongs to Central Nervous System.
Why it happens
Additive QT prolongation plus possible additive serotonergic effects.
What to do
Consider a baseline ECG and electrolyte check in patients with cardiac risk factors. Monitor for serotonin toxicity and choose an alternative antiemetic if risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Dolasetron with Trimipramine?
MediHelp rates the interaction as moderate. Dolasetron and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can prolong the QT interval and have serotonergic activity. With dolasetron this raises the potential for arrhythmia and, rarely, serotonin syndrome.
How serious is the interaction between Dolasetron and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a baseline ECG and electrolyte check in patients with cardiac risk factors. Monitor for serotonin toxicity and choose an alternative antiemetic if risk is high.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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