Drug interactions
Dolasetron + Valbenazine
Severity: Moderate
Dolasetron and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dolasetron prolongs the QT interval in a dose-related way. Valbenazine at higher exposures may cause modest QT prolongation, so the combination may add to the risk of arrhythmia. Risk is greater in patients with long QT, bradycardia or electrolyte disturbances.
What this interaction means in plain words
Dolasetron and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Valbenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Correct electrolyte abnormalities and consider ECG monitoring, particularly in patients with cardiac risk factors or CYP2D6/CYP3A4 inhibitors that raise valbenazine exposure. Choose a different antiemetic if risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Dolasetron with Valbenazine?
MediHelp rates the interaction as moderate. Dolasetron and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dolasetron prolongs the QT interval in a dose-related way. Valbenazine at higher exposures may cause modest QT prolongation, so the combination may add to the risk of arrhythmia. Risk is greater in patients with long QT, bradycardia or electrolyte disturbances.
How serious is the interaction between Dolasetron and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct electrolyte abnormalities and consider ECG monitoring, particularly in patients with cardiac risk factors or CYP2D6/CYP3A4 inhibitors that raise valbenazine exposure. Choose a different antiemetic if risk factors are present.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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