Drug interactions
Dolutegravir + Ferric maltol
Severity: Moderate
Dolutegravir and Ferric maltol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iron from ferric maltol can bind dolutegravir in the gut and decrease its absorption, risking reduced antiviral efficacy. Ferric maltol is taken on an empty stomach, which makes chelation more likely.
What this interaction means in plain words
Dolutegravir and Ferric maltol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolutegravir belongs to Anti Virals; Ferric maltol belongs to Miscellaneous.
Why it happens
Ferric iron chelates dolutegravir in the gastrointestinal tract, reducing absorption.
What to do
Take dolutegravir 2 hours before or 6 hours after ferric maltol, and monitor HIV viral load.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolutegravir
Other interactions of Ferric maltol
- Aluminum hydroxide + Ferric maltol Moderate
- Calcium carbonate + Ferric maltol Moderate
- Calcium + Ferric maltol Moderate
- Carbidopa-entacapone-levodopa + Ferric maltol Moderate
- Carbidopa-levodopa + Ferric maltol Moderate
- Cimetidine + Ferric maltol Moderate
Frequently asked questions
Can I take Dolutegravir with Ferric maltol?
MediHelp rates the interaction as moderate. Dolutegravir and Ferric maltol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iron from ferric maltol can bind dolutegravir in the gut and decrease its absorption, risking reduced antiviral efficacy. Ferric maltol is taken on an empty stomach, which makes chelation more likely.
How serious is the interaction between Dolutegravir and Ferric maltol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take dolutegravir 2 hours before or 6 hours after ferric maltol, and monitor HIV viral load.
What other medicines interact with Dolutegravir?
MediHelp also lists interactions of Dolutegravir with, for example, Dofetilide, Aluminum hydroxide, Atidarsagene autotemcel. The full list is on the Dolutegravir page.
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