Drug interactions
Dolutegravir + Nevirapine
Severity: Moderate
Dolutegravir and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may lower dolutegravir concentrations through enzyme induction, risking reduced antiviral efficacy. Data with nevirapine are limited, and the effect is expected to be smaller than with strong inducers.
What this interaction means in plain words
Dolutegravir and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolutegravir belongs to Anti Virals; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces UGT1A1 and CYP3A4, increasing dolutegravir metabolism.
What to do
Monitor HIV viral load closely and consider an alternative regimen if virological response is inadequate. Dolutegravir can be given twice daily in some inducer settings, but data for nevirapine are limited.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Dolutegravir
Frequently asked questions
Can I take Dolutegravir with Nevirapine?
MediHelp rates the interaction as moderate. Dolutegravir and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may lower dolutegravir concentrations through enzyme induction, risking reduced antiviral efficacy. Data with nevirapine are limited, and the effect is expected to be smaller than with strong inducers.
How serious is the interaction between Dolutegravir and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load closely and consider an alternative regimen if virological response is inadequate. Dolutegravir can be given twice daily in some inducer settings, but data for nevirapine are limited.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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