Drug interactions
Dopamine + Fenfluramine
Severity: Moderate
Dopamine and Fenfluramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine increases serotonin release and has some sympathetic effects, while dopamine is a direct and indirect adrenergic and dopaminergic agonist. Combined use may add to cardiovascular stimulation, and fenfluramine carries valvular and pulmonary hypertension risks that make hemodynamic instability more concerning.
What this interaction means in plain words
Dopamine and Fenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dopamine belongs to Cardiovascular; Fenfluramine belongs to Central Nervous System.
Why it happens
Additive sympathomimetic and monoaminergic pharmacodynamic effects.
What to do
Monitor blood pressure, heart rate and rhythm during dopamine infusion in patients taking fenfluramine. Adjust the dopamine dose to the hemodynamic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dopamine
- Dihydroergotamine intranasal + Dopamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dopamine + Promethazine Contraindicated
- Dopamine + Selegiline transdermal Contraindicated
- Amitriptyline + Dopamine Major
- Clomipramine + Dopamine Major
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Dopamine with Fenfluramine?
MediHelp rates the interaction as moderate. Dopamine and Fenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenfluramine increases serotonin release and has some sympathetic effects, while dopamine is a direct and indirect adrenergic and dopaminergic agonist. Combined use may add to cardiovascular stimulation, and fenfluramine carries valvular and pulmonary hypertension risks that make hemodynamic instability more concerning.
How serious is the interaction between Dopamine and Fenfluramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and rhythm during dopamine infusion in patients taking fenfluramine. Adjust the dopamine dose to the hemodynamic response.
What other medicines interact with Dopamine?
MediHelp also lists interactions of Dopamine with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Promethazine. The full list is on the Dopamine page.
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