Drug interactions
Dopamine + Midodrine
Severity: Moderate
Dopamine and Midodrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midodrine is an alpha-1 agonist and, with dopamine, produces additive vasoconstriction and blood pressure elevation. Excessive hypertension and reflex bradycardia or arrhythmias may occur.
What this interaction means in plain words
Dopamine and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dopamine belongs to Cardiovascular; Midodrine belongs to Miscellaneous.
Why it happens
Additive alpha-adrenergic vasopressor effects.
What to do
Monitor blood pressure and heart rate closely and adjust the dopamine infusion rate as the midodrine effect develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dopamine
- Dihydroergotamine intranasal + Dopamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dopamine + Promethazine Contraindicated
- Dopamine + Selegiline transdermal Contraindicated
- Amitriptyline + Dopamine Major
- Clomipramine + Dopamine Major
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Dopamine with Midodrine?
MediHelp rates the interaction as moderate. Dopamine and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midodrine is an alpha-1 agonist and, with dopamine, produces additive vasoconstriction and blood pressure elevation. Excessive hypertension and reflex bradycardia or arrhythmias may occur.
How serious is the interaction between Dopamine and Midodrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate closely and adjust the dopamine infusion rate as the midodrine effect develops.
What other medicines interact with Dopamine?
MediHelp also lists interactions of Dopamine with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Promethazine. The full list is on the Dopamine page.
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