Drug interactions
Dopamine + Propylhexedrine
Severity: Moderate
Dopamine and Propylhexedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propylhexedrine is a sympathomimetic decongestant, and with intravenous dopamine it may add to increases in blood pressure and heart rate. Systemic exposure is usually modest at normal inhaled doses but is greater with misuse.
What this interaction means in plain words
Dopamine and Propylhexedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dopamine belongs to Cardiovascular; Propylhexedrine belongs to Respiratory.
Why it happens
Additive sympathomimetic activity through indirect norepinephrine release and direct adrenergic stimulation.
What to do
Monitor blood pressure and heart rate during dopamine infusion and avoid use of propylhexedrine inhalers in patients on vasopressors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dopamine
- Dihydroergotamine intranasal + Dopamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dopamine + Promethazine Contraindicated
- Dopamine + Selegiline transdermal Contraindicated
- Amitriptyline + Dopamine Major
- Clomipramine + Dopamine Major
Other interactions of Propylhexedrine
- Isocarboxazid + Propylhexedrine Contraindicated
- Phenelzine + Propylhexedrine Contraindicated
- Linezolid + Propylhexedrine Major
- Propylhexedrine + Selegiline Major
- Propylhexedrine + Tranylcypromine Major
- Adrenaline-articaine + Propylhexedrine Moderate
Frequently asked questions
Can I take Dopamine with Propylhexedrine?
MediHelp rates the interaction as moderate. Dopamine and Propylhexedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propylhexedrine is a sympathomimetic decongestant, and with intravenous dopamine it may add to increases in blood pressure and heart rate. Systemic exposure is usually modest at normal inhaled doses but is greater with misuse.
How serious is the interaction between Dopamine and Propylhexedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during dopamine infusion and avoid use of propylhexedrine inhalers in patients on vasopressors.
What other medicines interact with Dopamine?
MediHelp also lists interactions of Dopamine with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Promethazine. The full list is on the Dopamine page.
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