Drug interactions
Dopamine + Tiotropium-olodaterol
Severity: Moderate
Dopamine and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dopamine given by infusion has adrenergic effects that add to those of the beta2 agonist olodaterol. This can lead to tachycardia, arrhythmias and blood pressure changes, particularly in critically ill patients.
What this interaction means in plain words
Dopamine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dopamine belongs to Cardiovascular; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive sympathomimetic stimulation of adrenergic receptors in the heart and vasculature.
What to do
Monitor heart rate, rhythm and blood pressure continuously during dopamine infusion. Consider holding the inhaled long-acting beta agonist while the patient is on vasopressor support.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Dopamine
- Dihydroergotamine intranasal + Dopamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dopamine + Promethazine Contraindicated
- Dopamine + Selegiline transdermal Contraindicated
- Amitriptyline + Dopamine Major
- Clomipramine + Dopamine Major
Frequently asked questions
Can I take Dopamine with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Dopamine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dopamine given by infusion has adrenergic effects that add to those of the beta2 agonist olodaterol. This can lead to tachycardia, arrhythmias and blood pressure changes, particularly in critically ill patients.
How serious is the interaction between Dopamine and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and blood pressure continuously during dopamine infusion. Consider holding the inhaled long-acting beta agonist while the patient is on vasopressor support.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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