Drug interactions
Doravirine + Ribociclib
Severity: Minor
Doravirine and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doravirine is cleared mainly by CYP3A4, and ribociclib may modestly raise its concentrations. Doravirine has a wide safety margin, so clinically significant effects are unlikely.
What this interaction means in plain words
Doravirine and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doravirine belongs to Anti Virals; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, reducing doravirine metabolism.
What to do
No dose adjustment is needed. Monitor for doravirine adverse effects such as nausea and headache.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Doravirine
- Amobarbital + Doravirine Contraindicated
- Apalutamide + Doravirine Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Doravirine + Efavirenz Contraindicated
- Doravirine + Enzalutamide Contraindicated
- Doravirine + Mitotane Contraindicated
Frequently asked questions
Can I take Doravirine with Ribociclib?
MediHelp rates the interaction as minor. Doravirine and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Doravirine is cleared mainly by CYP3A4, and ribociclib may modestly raise its concentrations. Doravirine has a wide safety margin, so clinically significant effects are unlikely.
How serious is the interaction between Doravirine and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for doravirine adverse effects such as nausea and headache.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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