Drug interactions
Dronabinol + Metoclopramide
Severity: Moderate
Dronabinol and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause central nervous system effects such as drowsiness, dizziness and dysphoria. Together they may increase sedation and impair psychomotor performance.
What this interaction means in plain words
Dronabinol and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronabinol belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depressant effects; metoclopramide's central dopamine antagonism adds to cannabinoid effects.
What to do
Counsel patients about additive drowsiness and avoid driving until response is known. Reduce doses if excessive sedation or agitation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Frequently asked questions
Can I take Dronabinol with Metoclopramide?
MediHelp rates the interaction as moderate. Dronabinol and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause central nervous system effects such as drowsiness, dizziness and dysphoria. Together they may increase sedation and impair psychomotor performance.
How serious is the interaction between Dronabinol and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about additive drowsiness and avoid driving until response is known. Reduce doses if excessive sedation or agitation develops.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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