Drug interactions
Dronedarone + Ivermectin
Severity: Minor
Dronedarone and Ivermectin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits P-glycoprotein and may increase ivermectin exposure. Clinical significance with usual single-dose ivermectin is likely small.
What this interaction means in plain words
Dronedarone and Ivermectin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dronedarone belongs to Cardiovascular; Ivermectin belongs to Anti Parasitic.
Why it happens
Dronedarone inhibits P-glycoprotein efflux of ivermectin.
What to do
No routine adjustment is needed; monitor for neurotoxic symptoms if ivermectin is given repeatedly or at high dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ivermectin
- Erdafitinib + Ivermectin Moderate
- Ivermectin + Lasmiditan Moderate
- Ivermectin + Quinidine Moderate
- Ivermectin + Rifampin Moderate
- Ivermectin + Sotorasib Moderate
- Ivermectin + Tepotinib Moderate
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Ivermectin?
MediHelp rates the interaction as minor. Dronedarone and Ivermectin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dronedarone inhibits P-glycoprotein and may increase ivermectin exposure. Clinical significance with usual single-dose ivermectin is likely small.
How serious is the interaction between Dronedarone and Ivermectin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for neurotoxic symptoms if ivermectin is given repeatedly or at high dose.
What other medicines interact with Ivermectin?
MediHelp also lists interactions of Ivermectin with, for example, Erdafitinib, Lasmiditan, Quinidine. The full list is on the Ivermectin page.
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