Drug interactions
Dronedarone + Nintedanib
Severity: Moderate
Dronedarone and Nintedanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits P-glycoprotein, which transports nintedanib, and may increase nintedanib exposure. This can worsen gastrointestinal effects such as diarrhea and nausea, and hepatic enzyme elevations.
What this interaction means in plain words
Dronedarone and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Nintedanib belongs to Oncology.
Why it happens
Dronedarone inhibits P-glycoprotein efflux of nintedanib, increasing its exposure.
What to do
Monitor for adverse effects and liver enzymes. Manage with symptomatic treatment, dose reduction or interruption of nintedanib if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Nintedanib
- Amiodarone + Nintedanib Moderate
- Apixaban + Nintedanib Moderate
- Argatroban + Nintedanib Moderate
- Azithromycin + Nintedanib Moderate
- Carbamazepine + Nintedanib Moderate
- Carvedilol + Nintedanib Moderate
Frequently asked questions
Can I take Dronedarone with Nintedanib?
MediHelp rates the interaction as moderate. Dronedarone and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone inhibits P-glycoprotein, which transports nintedanib, and may increase nintedanib exposure. This can worsen gastrointestinal effects such as diarrhea and nausea, and hepatic enzyme elevations.
How serious is the interaction between Dronedarone and Nintedanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects and liver enzymes. Manage with symptomatic treatment, dose reduction or interruption of nintedanib if toxicity occurs.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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