Drug interactions
Dronedarone + Pacritinib
Severity: Major
Dronedarone and Pacritinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone may increase pacritinib exposure. Pacritinib itself has QT-prolonging potential and bleeding and diarrhea risks, so higher levels are undesirable alongside a QT-prolonging drug.
What this interaction means in plain words
Dronedarone and Pacritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dronedarone belongs to Cardiovascular; Pacritinib belongs to Oncology.
Why it happens
Dronedarone inhibits CYP3A4, reducing pacritinib metabolism; additive QT effects are also possible.
What to do
Avoid the combination where possible. If used, monitor ECG and for pacritinib adverse effects, and reduce the dose if labeling advises.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Dronedarone with Pacritinib?
MediHelp rates the interaction as major. Dronedarone and Pacritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dronedarone may increase pacritinib exposure. Pacritinib itself has QT-prolonging potential and bleeding and diarrhea risks, so higher levels are undesirable alongside a QT-prolonging drug.
How serious is the interaction between Dronedarone and Pacritinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, monitor ECG and for pacritinib adverse effects, and reduce the dose if labeling advises.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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