Drug interactions
Dronedarone + Talazoparib
Severity: Moderate
Dronedarone and Talazoparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Talazoparib is a P-glycoprotein substrate, and dronedarone inhibits this transporter, so talazoparib exposure may increase. This could worsen myelosuppression such as anemia and thrombocytopenia.
What this interaction means in plain words
Dronedarone and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Talazoparib belongs to Oncology.
Why it happens
Dronedarone inhibits P-glycoprotein efflux of talazoparib.
What to do
Avoid if possible; otherwise consider reducing the talazoparib dose per labeling and monitor blood counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Talazoparib
- Carvedilol + Talazoparib Major
- Itraconazole + Talazoparib Major
- Amiodarone + Talazoparib Moderate
- Azithromycin + Talazoparib Moderate
- Clarithromycin + Talazoparib Moderate
- Cyclosporin + Talazoparib Moderate
Frequently asked questions
Can I take Dronedarone with Talazoparib?
MediHelp rates the interaction as moderate. Dronedarone and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Talazoparib is a P-glycoprotein substrate, and dronedarone inhibits this transporter, so talazoparib exposure may increase. This could worsen myelosuppression such as anemia and thrombocytopenia.
How serious is the interaction between Dronedarone and Talazoparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise consider reducing the talazoparib dose per labeling and monitor blood counts.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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