Drug interactions
Dulaglutide + Ertugliflozin-sitagliptin
Severity: Moderate
Dulaglutide and Ertugliflozin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dulaglutide is a GLP-1 receptor agonist and sitagliptin is a DPP-4 inhibitor, so both act on the incretin pathway and the combination offers little extra benefit. Adding ertugliflozin further lowers glucose, and overall hypoglycemia risk rises mainly if a sulfonylurea or insulin is also used.
What this interaction means in plain words
Dulaglutide and Ertugliflozin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dulaglutide belongs to Endocrine; Ertugliflozin-sitagliptin belongs to Endocrine.
Why it happens
Overlapping incretin-pathway activity plus additive glucose lowering from SGLT2 inhibition.
What to do
Generally avoid combining a DPP-4 inhibitor with a GLP-1 agonist; if used, monitor glucose and reduce any sulfonylurea or insulin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Dulaglutide
Frequently asked questions
Can I take Dulaglutide with Ertugliflozin-sitagliptin?
MediHelp rates the interaction as moderate. Dulaglutide and Ertugliflozin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dulaglutide is a GLP-1 receptor agonist and sitagliptin is a DPP-4 inhibitor, so both act on the incretin pathway and the combination offers little extra benefit. Adding ertugliflozin further lowers glucose, and overall hypoglycemia risk rises mainly if a sulfonylurea or insulin is also used.
How serious is the interaction between Dulaglutide and Ertugliflozin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Generally avoid combining a DPP-4 inhibitor with a GLP-1 agonist; if used, monitor glucose and reduce any sulfonylurea or insulin dose.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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