Drug interactions
Duloxetine + Epcoritamab
Severity: Moderate
Duloxetine and Epcoritamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epcoritamab induces cytokine release that can temporarily suppress hepatic CYP enzyme activity. Duloxetine depends on CYP1A2 and CYP2D6 for clearance, so concentrations may rise during cytokine release syndrome and increase its adverse effects.
What this interaction means in plain words
Duloxetine and Epcoritamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Epcoritamab belongs to Oncology.
Why it happens
Cytokine-driven suppression of CYP1A2 and CYP2D6 activity lowers duloxetine clearance.
What to do
Monitor for duloxetine toxicity (nausea, dizziness, agitation, blood pressure rise) during the first treatment cycles and CRS episodes. Adjust the duloxetine dose if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Epcoritamab
- Epcoritamab + Ergotamine Major
- Epcoritamab + Pimozide Major
- Bendamustine + Epcoritamab Moderate
- Carbamazepine + Epcoritamab Moderate
- Clomipramine + Epcoritamab Moderate
- Clozapine + Epcoritamab Moderate
Frequently asked questions
Can I take Duloxetine with Epcoritamab?
MediHelp rates the interaction as moderate. Duloxetine and Epcoritamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epcoritamab induces cytokine release that can temporarily suppress hepatic CYP enzyme activity. Duloxetine depends on CYP1A2 and CYP2D6 for clearance, so concentrations may rise during cytokine release syndrome and increase its adverse effects.
How serious is the interaction between Duloxetine and Epcoritamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for duloxetine toxicity (nausea, dizziness, agitation, blood pressure rise) during the first treatment cycles and CRS episodes. Adjust the duloxetine dose if symptoms occur.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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