Drug interactions
Duloxetine + Ergotamine
Severity: Major
Duloxetine and Ergotamine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents act on serotonergic pathways, raising the possibility of serotonin syndrome. Ergotamine also causes strong vasoconstriction, and duloxetine can raise blood pressure, adding to vascular risk.
What this interaction means in plain words
Duloxetine and Ergotamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Duloxetine belongs to Central Nervous System; Ergotamine belongs to Central Nervous System.
Why it happens
Additive serotonergic effects, with additive vasoconstrictive and pressor effects.
What to do
Avoid the combination where possible and choose another migraine therapy. If used, monitor for serotonin toxicity, hypertension and ischemic symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Duloxetine with Ergotamine?
MediHelp rates the interaction as major. Duloxetine and Ergotamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents act on serotonergic pathways, raising the possibility of serotonin syndrome. Ergotamine also causes strong vasoconstriction, and duloxetine can raise blood pressure, adding to vascular risk.
How serious is the interaction between Duloxetine and Ergotamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose another migraine therapy. If used, monitor for serotonin toxicity, hypertension and ischemic symptoms.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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