Drug interactions
Duloxetine + Fedratinib
Severity: Moderate
Duloxetine and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate inhibitor of CYP2D6, one of the main enzymes that metabolize duloxetine. Duloxetine exposure may increase, raising the chance of nausea, dizziness, blood pressure elevation and serotonergic effects.
What this interaction means in plain words
Duloxetine and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Fedratinib belongs to Oncology.
Why it happens
Fedratinib inhibits CYP2D6, reducing duloxetine clearance.
What to do
Monitor for duloxetine adverse effects when fedratinib is started and consider a lower duloxetine dose if tolerability worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Duloxetine with Fedratinib?
MediHelp rates the interaction as moderate. Duloxetine and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate inhibitor of CYP2D6, one of the main enzymes that metabolize duloxetine. Duloxetine exposure may increase, raising the chance of nausea, dizziness, blood pressure elevation and serotonergic effects.
How serious is the interaction between Duloxetine and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for duloxetine adverse effects when fedratinib is started and consider a lower duloxetine dose if tolerability worsens.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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