Drug interactions
Duloxetine + Gepirone
Severity: Major
Duloxetine and Gepirone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gepirone is a 5-HT1A agonist antidepressant, and combining it with a serotonin-norepinephrine reuptake inhibitor raises the risk of serotonin syndrome. Using two antidepressants is also generally unnecessary. Gepirone is also metabolized by CYP3A4, but duloxetine is not a meaningful inhibitor of it.
What this interaction means in plain words
Duloxetine and Gepirone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Duloxetine belongs to Central Nervous System; Gepirone belongs to Central Nervous System.
Why it happens
Additive serotonergic activity from 5-HT1A agonism and serotonin-norepinephrine reuptake inhibition.
What to do
Avoid combining unless clearly needed; if used, monitor for serotonin syndrome at initiation and dose changes. Stop one agent if symptoms appear.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Duloxetine with Gepirone?
MediHelp rates the interaction as major. Duloxetine and Gepirone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gepirone is a 5-HT1A agonist antidepressant, and combining it with a serotonin-norepinephrine reuptake inhibitor raises the risk of serotonin syndrome. Using two antidepressants is also generally unnecessary. Gepirone is also metabolized by CYP3A4, but duloxetine is not a meaningful inhibitor of it.
How serious is the interaction between Duloxetine and Gepirone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining unless clearly needed; if used, monitor for serotonin syndrome at initiation and dose changes. Stop one agent if symptoms appear.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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