Drug interactions
Duloxetine + Methamphetamine
Severity: Moderate
Duloxetine and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine moderately inhibits CYP2D6, which can raise methamphetamine exposure. Both drugs also increase monoaminergic activity, so serotonergic and cardiovascular effects such as hypertension, tachycardia and agitation may be amplified.
What this interaction means in plain words
Duloxetine and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Methamphetamine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by duloxetine reduces methamphetamine metabolism, plus additive serotonergic and noradrenergic effects.
What to do
Monitor blood pressure, heart rate and signs of serotonin toxicity or excessive stimulation. Reduce the methamphetamine dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Duloxetine with Methamphetamine?
MediHelp rates the interaction as moderate. Duloxetine and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duloxetine moderately inhibits CYP2D6, which can raise methamphetamine exposure. Both drugs also increase monoaminergic activity, so serotonergic and cardiovascular effects such as hypertension, tachycardia and agitation may be amplified.
How serious is the interaction between Duloxetine and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and signs of serotonin toxicity or excessive stimulation. Reduce the methamphetamine dose if adverse effects occur.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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